Procaine Penicillin Administered Orally: Comparison with Sodium Penicillin

Treatment of gonorrhoea with cotrimoxazole, procaine penicillin alone, and procaine penicillin plus probenecid.

Successful treatment of gonorrhoea with cotri-moxazole* has now been reported by several workers who gave one tablet four times a day for 5 days, observed a failure rate of 38 per cent. of the 86 men followed. They claimed that in 45 per cent. of the failures a carrier state resulted which was detected by routine examination of Gram-stained smears in all cases after treatment; cultures were not...

High dosage procaine penicillin combined with ampicillin in the treatment of gonorrhoea after failure with standard procaine penicillin dosage.

This is a preliminary report suggesting a method of management of cases of gonorrhoea in which there has been failure of treatment with standard doses of penicillin. Over the past 10 years there has been a steady increase in the number of strains of gonococci isolated which show an increased resistance to the action of penicillin (Curtis and Wilkinson, 1958). The Medical Research Council (1961)...

Toxic epidermal necrolysis due to procaine penicillin.

I toxic epidermal necrolysis (TEN), a wide layer of skin is peeled and an immature skin layer appears. In a short period, an epidermal necrolysis characterized by scalded appearance of skin due to febrile toxic reaction develops. The mortality rate of this disease is high (20-70%), due to dramatic drug reactions of the skin. The disease resembles mostly to erythema multiforme (EM), Steven Johns...

Procaine penicillin with aluminium monostearate; infrequent injections for children.

OF all the methods of delaying the absorption of intramuscular penicillin, combination with procaine is at present foremost (Florey 1952). Procaine penicillin is most effective when the particles are smaller than 5 µ and are suspended in a peanut-oil medium with 2% (w/v) aluminium monostearate (Thomas et al. 1948). Emery et al. (1949) showed that in children a serum-penicillin level above...

Treatment of gonorrhoea with procaine penicillin plus probenecid.